PharmPK Discussion - CYP isozymes

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On 21 Apr 2000 at 21:24:33, aashaw.-at-.sparky.pharmacy.purdue.edu sent the message


Midazolam is a good substrate to utilize to probe for CYP3A
enzyme activities in a rat.  Please refer to the following references
for midazolam.

Higashikawa, F. et al. J.Pharm.Pharmacol.51(1):1999, 67-72.
Higashikawa, F. et al. J.Pharm.Pharmacol.51(4):1999, 405-510.
Wandel, C. et al. Br.J.Anaesth.73:1994,658-661.

Testosterone is also able to probe for CYP3A enzyme activities in
addition to CYP2C11 and CYP2B enzyme activites.  Please refer
to the following references for testosterone.

Imaoka, S. et al. J. Biochem. 104(3):1988,481-487.
Farrell, G. and A.Koltai. Gastroenterology. 95(2):1988, 425-433.
Waxman, D.J. et al. Mol. Pharmacol. 32: 1987, 615-624.
Waxman, D.J. Biochem.Pharmacol. 37(1):1988, 71-84.

I hope this information helps.

Andrew Shaw
Ph.D. Candidate
Industrial & Physical Pharmacy Department
Purdue University

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On 27 Apr 2000 at 20:03:32, furlanut.aaa.HYDRUS.CC.UNIUD.IT sent the message


You can find some useful referenxces at the following URL:
http://www.dml.georgetown.edu/depts/pharmacology/davetab.html
Regards
---
Federico Pea, MD
Institute of Clinical Pharmacology & Toxicology
University of Udine
Italy

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