PharmPK Discussion - Data for absorption model

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On 7 Dec 2000 at 15:45:01, marta (marta.aaa.ariel1.ucsf.edu) sent the message


Dear collegues,

   We are developing a model for differential absorption in the GI with the
ultimate purpose to obtain a better in-vitro/in-vivo correlation.
    We have pretty much developed the model but we cannot find a nice data set
for an example.

    The ideal data would consist of concentration vs time data for one
drug given
by:

1. IV
2. Oral, IR  (or better yet, solution)
3. Intubation with solution given at one or more different levels of GI tract
4. sustained release  with known in vitro release rate profile is known.

The various "experiments" above could be done in the same persons, or different
persons, so long as they were all "normals" or otherwise similar.

Does any of you know of any such data that we could get?

Thank you in advance

Kind regards,

Marta

Marta Valle, Ph.D.
Department of Biopharmaceutical Sciences
Box 0446
School of Pharmacy
University of California at San Francisco
513 Parnassus Avenue
San Francisco, CA  94143-0446

Phone: (415) 502-6685

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On 8 Dec 2000 at 13:41:40, han_waterbeemd.-a-.sandwich.pfizer.com sent the message


See all the nice work done by Hans Lennernas and his hroup at the University
of Uppsala.

Han

Dr. Han van de Waterbeemd
Pfizer Global Research and Development
PDM (Drug Metabolism Sandwich)
Manager Discovery & Preclinical Development
IPC 331
Sandwich, Kent CT13 9NJ, UK
Tel. +44-1304-646179
Fax +44-1304-656433
han_waterbeemd.-a-.sandwich.pfizer.com

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