PharmPK Discussion - Distribution of terbinafine or other lipophilic

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On 22 Sep 2000 at 10:27:31, Erik Fred Oscar Pomp (efpo.-at-.haukeland.no) sent the message


Title:
Distribution of terbinafine or other lipophilic substances into bone marrow?

Dear all,
We are facing an unusual case of cytopenia (granulocytopenia, leucopenia,
thrombocytopenia, not recovered after four months) which we think is an
adverse reaction to terbinafine. Reported cases tended to normalise within
to weeks. We are looking for all possible explanations, including a
theoretical pharmacokinetic one. Terbinafine is known to accumulate in
fat/adipose tissue and keratinic tissues. Terminal half lives upto 400 hours
have been reported. How about distribution of terbinafine or other
lipophilic substances into bone marrow? Any, preferably quick, response
would be highly appreciated.

Kind regards

Erik F.O. Pomp
tel.  +47 55 97 53 61
fax. +47 55 29 07 18
e-mail relis3.at.haukeland.no
www.relis.org/

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