PharmPK Discussion - Dose of Galactosamine

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On 26 Sep 2000 at 10:12:30, ychugh.at.wockhardtin.com sent the message


Hi, All,

What is the dose of Galactosamine to produce Acute liver dysfunction in
Mice.

Thanks.

Y.Chugh

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On 27 Sep 2000 at 10:37:05, "Mike McLane" (MMCLANE.-at-.magainin.com) sent the message


I empirically determined that 7 or 8 mg/mouse (i.e. about 350 mg/kg)
i.p. galactosamine would cause liver dysfunction  and would sensitize
the mice to endotoxin as a model.    Hope this helps.

Mike

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