PharmPK Discussion - First pass metabolism in rats

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On 16 Feb 2000 at 21:48:12, Mubeen Khan (mkhan.aaa.looksmart.com.au) sent the message


Dear All,

I want to study the First pass metabolism of one of my compounds in
rats.

Would appreciate if some one can suggest a brief protocol to do that.

thanks.
M.Khan

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On 17 Feb 2000 at 21:47:02, David_Bourne (david.aaa.boomer.org) sent the message


[Two replies - db]

Date: Thu, 17 Feb 2000 07:34:11 -0500
From: "Cotler, Stanley {NCDS~Nutley}" 
Subject: RE: PharmPK First pass metabolism in rats
To: "'PharmPK.-a-.boomer.org'" 

See work by Colburn,W  and also myself. Need to do intraportal administation.

Stanley C

Stanley Cotler

Department of Non-Clinical Drug Safety

Phone (973) 235-2857 Fax (973) 235-7010

E-Mail Stanley.Cotler .-a-.Roche.com

Nutley
---

X-OpenMail-Hops: 1
Date: Thu, 17 Feb 2000 09:21:38 -0500
Subject: Re: PharmPK First pass metabolism in rats
From: Tong_William/mskcc_MOL.aaa.mskmail.mskcc.org
TO: PharmPK.at.boomer.org

     Dear Dr. Khan,

     You can use a perfused rat liver model.

     Bill Tong

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On 18 Feb 2000 at 20:59:49, "Muhammad D. Hussain" (Delwar.-a-.uwyo.edu) sent the message


	For hepatic first-pass metabolism, you can use in-vitro or in-situ
perfused rat liver model.  If the first-pass effect is in the gut, you can
use in-vitro rat inverted gut model.  You can calculate e.g. extraction
ratio and quantitate metabolites formed.  If you need any reference please
let me know.

M. Delwar Hussain, Ph.D.
Associate Professor
School of Pharmacy
University of Wyoming
Laramie, WY 82071-3375
Tel: 307 766 6129
Fax: 307 766 2953

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