PharmPK Discussion - In vivo in Vitro correlation

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On 10 Feb 2000 at 22:18:33, Eric.Magnan.-at-.beaufour-ipsen.com sent the message


Dear Members,

I'm currently working on slow release peptide formulation and I have hard time
to figure a good correlation (level  B or C) between in vivo and in vitro
release.

I have question:
     - concerning sustained release formulation: from your knowledge is
there in the literature examples of good correlation between in vivo and in
vitro???
     - to replace an in vivo test by an in vitro test what kind of correlation
level is necessary A B or C???

Thanking you in advance for your cooperation.

  Eric MAGNAN, PhD
  LAB PHARMA BIOTECH

  83330 SIGNES CEDEX; FRANCE

  Tel: 33 4 94 10 76 76
  Fax: 33 4 94 10 76 79

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