PharmPK Discussion - Lipid emulsions of anaesthetic drugs

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On 18 Apr 2000 at 22:22:52, mmorgan.at.postoffice.utas.edu.au sent the message


Dear investigators,

I am currently researching "lipid emulsions" (eg. Diprivan) used in the iv
formulation of anaesthetic drugs. I am eager to learn how these formulations
accelerate the rate of onset/offset of pharmacologic effect by enhancing the
rate of effect-site uptake & turnover, which in turn accelerates systemic
elimination kinetics & reduces the extent of body distribution of the drug.
I am largely concerned with the physico-chemical properties of these
emulsions and their effect on PK. Could anyone direct me to some references?

Regards
Mark Morgan
University of Tasmania

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