PharmPK Discussion - Metabolism of clonidine in humans

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On 26 Apr 2000 at 21:30:36, Petter Cappelen Endresen (pettere.at.fagmed.uit.no) sent the message


Does anyone know whether there are CYPs involved in the metabolism of
clonidine (Catapresan)? Thanks in advance.
Petter Endresen, MD, PhD
Dept Pharmacology, University of Tromso
Norway

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On 27 Apr 2000 at 20:05:42, David_Bourne (david.-a-.boomer.org) sent the message

[Two replies - db]

Date: Thu, 27 Apr 2000 01:16:41 -0700 (MST)
X-Sender: ml11439.-at-.pop.goodnet.com
To: PharmPK.aaa.boomer.org
From: ml11439.aaa.goodnet.com (Michael J. Leibold)
Subject: Re: PharmPK Metabolism of clonidine in humans

Dr.Endressen,

     This reference indicates that clonidine is predominantly cleared
renally (62%), and that "the plasma clonidine concentration produced
by a particular transdermal dose varies considerably between individuals
as a result of interindividual variation in renal clearance."

Unique Identifier
   88282956
Authors
   Lowenthal DT.  Matzek KM.  MacGregor TR.
Institution
   Department of Geriatrics and Adult Development, Mt Sinai School of Medicine,
   New York.
Title
   Clinical pharmacokinetics of clonidine. [Review] [140 refs]
Source
   Clinical Pharmacokinetics.  14(5):287-310, 1988 May.

                  Mike Leibold, PharmD, RPH
                  ML11439.aaa.goodnet.com

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From: HRr1234.-at-.aol.com
Date: Thu, 27 Apr 2000 13:05:48 EDT
Subject: Re: PharmPK Metabolism of clonidine in humans
To: PharmPK.-at-.boomer.org

I suggest you contact Boehrimger Ingelheim medical information - the
originators of Catapres, 800-243-0127 or 800-542-6257.

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