PharmPK Discussion - Missing covariates

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On 7 Jun 2000 at 18:43:59, "Jean-Xavier.Mazoit.-at-.kb.u-psud.fr" (jean-xavier.mazoit.-a-.kb.u-psud.fr) sent the message


The following message was posted to: PharmPK

Dear NMusers,
I am concerned by missing covariates.  I did not find a lot of papers
dealing with that subject.  Could anyone send me references on that subject=
 ?
Thank you in advance.

Jean Xavier Mazoit MD, PhD

Laboratoire d'Anesth=E9sie
Universit=E9 Paris-Sud
Facult=E9 de M=E9decine du Kremlin-Bic=EAtre
F-94276 Bic=EAtre France
Tel.	(33) (0)1 49 59 67 35-37
	(33) (0)1 45 21 34 41 (Hopital)
Fax	(33) (0)1 45 21 28 75
e-mail	Jean-Xavier.Mazoit.-a-.kb.u-psud.fr

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On 12 Jun 2000 at 11:05:51, Mats Karlsson (Mats.Karlsson.-at-.biof.uu.se) sent the message


Dear Jean-Xavier,

Missing covariates is a wide topic.  For the particular case of missing
covariates in Pop PK, we described an approach in
Karlsson MO, Jonsson EN, Wiltse CG, Wade JR.
Assumption testing in population pharmacokinetic models: illustrated with an
analysis of moxonidine data from congestive
heart failure patients.
J Pharmacokinet Biopharm. 1998 Apr;26(2):207-46

Best regards,
Mats
--
Mats Karlsson, PhD
Professor of Biopharmaceutics and Pharmacokinetics
Div. of Biopharmaceutics and Pharmacokinetics
Dept of Pharmacy
Faculty of Pharmacy
Uppsala University
Box 580
SE-751 23 Uppsala
Sweden
phone +46 18 471 4105
fax +46 18 471 4003
mats.karlsson.-at-.biof.uu.se

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