PharmPK Discussion - Modified Wagner-Nelson method

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On 6 Jan 2000 at 21:10:23, "Sally Y. Choe" (salch.-at-.umich.edu) sent the message


Hello!
I have been using modified Wagner-Nelson method in Kinetica2000 to
obtain absorption rates from oral plasma data.
Where can I get more information on the topic of modified Wagner-Nelson
method?
I would like to find out how modified Wagner-Nelson method works.
Thank you for your help.

Sally Choe-

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On 7 Jan 2000 at 21:50:11, ml11439.-at-.goodnet.com (Michael J. Leibold) sent the message


Sally,

     Some references on the Wagner-Nelson method:

1) Wagner, John G., Fundamentals of Clinical Pharmacokinetics, Hamilton,
    Drug Intelligence Publications 1975:pp 173-200
2) Wagner, J.G. and Nelson, E., Percent absorbed time plots derived from
blood levels and/or urinary excretion data, J.Pharm.Sci 1963;52:610-611
3) Wagner, J.G., Application of the Wagner-Nelson model to the two compartment
open model, J Pharmacokin Biopharm 1974;2:469-486

              Mike Leibold, PharmD, RPH
              ML11439.-a-.goodnet.com

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