PharmPK Discussion - Organ metabolism

PharmPK Discussion List Archive Index page

On 17 Jun 2000 at 08:35:26, "Arlin Blood" (ablood.-a-.som.llu.edu) sent the message


Hi,

Is anyone aware of a reliable method(s) for measuring organ-specific
metabolism (e.g. oxygen consumption, respiration rate) in vivo, other than
the various imaging techniques being used?  For example, monitoring changes
in the metabolic rate of the brain or kidney during hypoxic/ischemic
episodes by looking at blood flow and arterial-venous PO2 levels or organ
heat production?  I'd be grateful for any references you can provide on the
topic.

Thank-you,

Arlin Blood
ablood.at.som.llu.edu

Back to the Top

On 23 Jun 2000 at 20:35:00, "howard s mehler phd jd & assoc inc" (hmehler.aaa.mehler.com) sent the message


Hi
     There are several older methods which enable organ specific measurement
of blood flow, metabolic rate and oxygen consumption.  Most medical
physiology textbooks describe the Kety Method  using nitrous oxide for
measurement of cerebral blood flow.  In the 1970's Sokoloff developed a
deoxyglucose method for measurement of cerebral metabolic rate.  And I think
cerebral oxygen consumption (cerebral metabolic rate for O2) can be measured
with arteriovenous differences.
                                                             Howard Mehler
                                                             Howard S Mehler
PhD JD & Associates Inc

hmehler.-a-.mehler.com

Back to the Top

Want to post a follow-up message on this topic? If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Organ metabolism" as the subject

PharmPK Discussion List Archive Index page