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I search a HPLC method to analyse in serum, an antibiotic,
cephalosporin = ceftazidime.
Could you help me to find it, please ?
Thank you for your help.
Laurence MANGIN
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Here is a reference for a paper with a validated method:
Vinks AATMM, Touw DJ, Heijerman HGM, Danhof M, de Leede GPJ, and
Bakker W. Pharmacokinetics of ceftazidime in adult cystic fibrosis
patients during continuous infusion and ambulatory treatment at home.
Ther Drug Monit 1994;16:341-8.
*****
Alexander A. Vinks, PharmD, PhD,
Research Professor of Pediatrics
Pharmacology Research Center & Clinical Trials Office
Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati, Ohio 45229-3039
Tel: (513) 636-0159; (513) 636-0160 (secretary).
Fax: (513) 636-0168.
CHMCC email: sander.vinks.-a-.chmcc.org
******
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Hope these will help.
Guitton et al (1998) "Determination of ceftazidime in plasma using =
high-performance liquid chromatography and electrochemical detection. =
Application for individualizing dosage regimens in elderly patients" J =
Chromatogr B Biomed Sci Appl 719 (1-2) 151-7
Farina et al (1999) "Stability of reconstituted solutions of ceftazidime =
for injections: an HPLC and CE approach" J Pharm Biomed Anal 20 (3) =
521-30
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Kanjana Imsilp
imsilp.at.uiuc.edu
Department of Veterinary Biosciences
University of Illinois at Urbana-Champaign
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