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Dear Collegues,
I am looking for a reliable physiological PK modeling software. Is there one
(commercially) available?
Thanks.
Sincerely,
Corinne Campanella
Pharmacokineticist
Clinical Pharmacology - GW Canada
Phone : 905-819-3464
Fax : 905-819-3356
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You can try SAAM II. This software have two modules and in compartmental
module you can build your physiological model if you have enough input and
output data (information) available. For more information, you can search
SAAM institute in web.(http://www.saam.com/) and they have workshop for
helping people to start working with SAAM II.
Zhao Wang
Anesthesia Rearch
Northwestern Univ. Medical School
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Scientist is a good start, stats are built in. Almost any stat package
could be
used to construct a model.. Logistic type regressions are most flexible and
report out corr stats, fit stats and probability.
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Try SAAM II.
http://www.saam.com
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Attn: Corinne Campanella,
SAAM II modeling software should meet all of your needs. A free demo is
available at saam.com. The SAAM Institute also offers modeling workshops for
those interested in learning more about modeling. If you have any questions,
you can reach our office at info.-a-.saam.com.
Bob Peterson
SAAM Institute
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This can be done with any PK modelling package using differential equation
(e.g. ADAPT II, Kinetica, WinNonlin). However, I'm not sure that libraries
for these models are available with these packages. You probably have to
write your own diff.equations.
The difficulty with physiologic modelling is usually to get organ flows in
each organ.
emasson.-a-.anapharm.com
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The following message was posted to: PharmPK
>This can be done with any PK modelling package using differential equation
>(e.g. ADAPT II, Kinetica, WinNonlin). However, I'm not sure that libraries
>for these models are available with these packages. You probably have to
>write your own diff.equations.
>
>The difficulty with physiologic modelling is usually to get organ flows in
>each organ.
Organ volumes as % of body weight and organ blood flows as % cardiac output
have been intensively studied for several species. See
Brown et al., Physiological parameter values for physiologically based
pharmacokinetic models, Toxicology and Industrial Health, 13: 407-484 (1997).
The real problem is the inadequacy of drug-specific parameters such as
equilibrium partitioning between tissues and blood, extraction ratios for
various tissues, and biochemical constants for metabolism of the drug (and
possibly its metabolite if the metabolite is the active form of the drug).
--
Michael C. Kohn
Laboratory of Computational Biology and Risk Analysis
National Institute of Environmental Health Sciences
P.O. Box 12233, Mail Drop A3-06
Research Triangle Park, NC 27709-2233
919-541-4929 (voice)
919-541-1470 (Fax)
E-mail: kohn.-a-.valiant.niehs.nih.gov
Web site: http://valiant.niehs.nih.gov
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Dear Ms. Campanella:
You might consider the USC*PACK programs. There is software
for parametric
and nonparametric modeling for any system where you enter the differential
equations, output euqations, and parameter names. A screen oriented
program, BOXES, helps make compartmental models of any type, generating the
fortran source code for the structural model. For the computations, there
is access (currently free)to the Cray T3E and IBM Blue Horizon machines at
the San Diego Supercomputer Center where we have an NIH supporter research
resource for population PK/PD modeling. Physiologic models would be well
analyzed by these tools. Let me know if you would like more info. Other
general info is below.
Very best regards,
Roger Jelliffe
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)