PharmPK Discussion - Plasma Css value and Therapeutic Index values of Ibuprofen

PharmPK Discussion List Archive Index page

On 20 Jul 2000 at 09:03:27, dabhijit.-at-.cheminor.com sent the message


Dear Pharmacokinetists,
Do anyone knows Plasma Css value and Therapeutic Index values of Ibuprofen?
Kindly reply at the following E. Mail ID

Yours Sincerely

A. M. Deshmukh
E. Mail : dabhijit.aaa.cheminor.com

Back to the Top

On 21 Jul 2000 at 12:42:01, William Heybroek (william.heybroek.aaa.kinetics.demon.co.uk) sent the message


Hi - I am not sure what you mean by Therapeutic Index.  We did a study
of ibuprofen in young and elderley (re. Kings College Hospital with
permission) but didn't dose by infusion. However I have results for
single bolus dose of 400mg ibuprofen which may help.  Mean AUC(0-inf)
for the unbound R- and S-enantiomers in healthy young subjects were 147
and 356 ng.h/ml.  The results for total R- and S- enantiomers were 63.6
and 82.8 ug.h/ml respectively.  The corresponding values for Cmax were
37.8, 70.2 ng/ml and 16.0 and 16.6 ug/ml.  As you can see the S(-)
enantiomer is predominant and is the pharmacologically active isomer.
You will have to take the interconversion of S- to R- into account as
this is causes loss of therapeutic activity following dosing.

Hope this is of some help.

Kind regards,

William Heybroek
PK Pharma

Back to the Top

Want to post a follow-up message on this topic? If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Plasma Css value and Therapeutic Index values of Ibuprofen" as the subject

PharmPK Discussion List Archive Index page