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[A busy day - remember there is a digest mode for this list if
individual message are causing too much traffic ;-) - db]
Do anybody know about a commercial source of pseudohypericin (a
constituent of Saint John's Wort)? We purchased hypericin from Sigma.
Also, do any of you know about recent analytical methods of
hyperecin and pseudohypericin?
Thanks for your help. Delwar
M. Delwar Hussain, Ph.D.
Associate Professor
School of Pharmacy
University of Wyoming
Laramie, WY 82071-3375
Tel: 307 766 6129
Fax: 307 766 2953
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Following references might help.
1. The development and evaluation of an HPLC-DAD method for the analysis of
the phenolic fractions from in vivo and in vitro biomass of Hypericum
species, J.Liq. Chrom. & Rel. Technol., 22(2), 215-217 (1999)
2.Determination of napthodianthrones in plant extracts from Hypericum
perforatum L. by liquid chromatography-electrospray mass spectrometry., J.
Chromatogr. B, 695 (1997) 309-316
3. High performance liquid chromatographic determination of the
biologically active principle hypericin in phytotherapeutic vegetable
extracts and alcoholic beverages, J. Chromatogr. A, 1996, 731(1-2), 336-339.
4. HPLC analysis of hypericin with photodiode array and MS detection: The
advantages of multispectral techniques, LC-GC, 17(6), June 1999, 556-562.
In our laboratory we use electrochemical detection for hypericin assay.
Chandrani Gunaratna
Chandrani Gunaratna, Ph.D.
Senior Research Scientist
Bioanalytical Systems
2701 Kent Avenue
West Lafayette, IN 47906
Phone: (765)463-4527
E-Mail: prema.-at-.bioanalytical.com
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There was a poster presented at a recent meeting of the
Canadian Society of Hospital Pharmacists:
"Analysis of the Hypericin and Pseudohypericin Content of
Commercially Available St. John's Wort Preparations."
The work was done by Scott Walker's group at Sunnybrook
and Women's College Health Sciences Centre in Toronto.
You can reach Scott at scott.walker.-at-.swchsc.on.ca
*******
Randy Trinkle, BScPharm, BA
Pharmacy Department
Prince Rupert Regional Hospital
Prince Rupert, BC
mailto:rtrinkle.-a-.mail.citytel.net
Health Science links:
http://www.rupert.net/~rtrinkle
********
I'll only say this once. 1999 is NOT the
last year of the 20th century.
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