PharmPK Discussion - Absorption pharmacokinetics

• On 7 Aug 2013 at 20:49:05, Chandramouli Radhakrishnan sent the message
  

  
  Hi,
  
  I am trying to calculate absorption PK for a drug (paracetamol) in healthy adult volunteers.
  Initial though was to use the method of residual to calculate, but I don't have IV data for this
  study.
  Could someone tell me how I can go about doing this.  I was thinking of using data from previous
  publications (iv data)  is this a right approch?
  
  --
  Kind Regards
  
  Radhakrishnan
  
  

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• On 8 Aug 2013 at 08:54:43, David S. Farrier sent the message
  

  
  Hello Radhakisham,
  
  If you have sufficient number of conc.-time sample data points (minimally, about 8-10) the method of
  residuals (curve stripping) can define the kinetic rate and intercept values for up to three
  distribution phases (compartments) such as absorption, distribution, and terminal elimination. Or
  serve as seed values for iterative analyses (e.g., curve fitting and compartmental modeling).
  
  Regards,
  
  David S. Farrier, Ph.D.
  Summit Research Services
  PK Solutions Data Analysis - www.SummitPK.com
  Montrose, CO 81401 USA
  DFarrier.aaa.SummitPK.com
  
  

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• On 8 Aug 2013 at 08:58:57, William Wolowich sent the message
  

  
  Radhakrishnan:
  You will need to use deconvolution to do this you will need IV and PO data from the same subject,
  preferably at the same time! Please look up the "semisimultaneous method" and deconvolution.
  
  

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