PharmPK Discussion - BCS Classification of drugs

• On 1 Oct 2013 at 09:13:49, ashwini kutwal (ashwini.kutwal.-at-.gmail.com) sent the message
  

  
  Hello,
    I have one query. As Dicloxaciilin having good solubility in water and also have good permeation
  then why it is listed in class lll drugs.
  
  

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• On 2 Oct 2013 at 08:49:52, Manisha (manishab.-a-.anazeal.com) sent the message
  

  
  Dear Ashwini,
  Dicloxacillin is having very high degree of plasma protien binding
  therefore though it is having good water solubility and also have good
  permeation it appear to have a diffusion limited exchange rate between the
  blood and tissue and are not flow limited.
  
  

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• On 2 Oct 2013 at 10:09:54, Rajendra Dhande (rajendrahd.-a-.gmail.com) sent the message
  

  
  Hello,
  
  I hope the answer by Manishab can resolve your query. For better clarification fin d below given
  link for detailed understanding
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130020/pdf/1472-6904-2-7.pdf
  
  Regards-Rajendra Dhande
  
  

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