PharmPK Discussion - Capillary versus venous hematocrit

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On 22 Jan 2013 at 13:58:37, "Remmerie, Bart [JRDBE]" (BREMMERI.-at-.its.jnj.com) sent the message


Does anyone know whether the hematocrit  -in adults- is different when
sampling blood from veins versus finger capillaries? And whether finger
manipulation (squeezing finger, warming up finger) or other
factors/covariates can induce such difference? Any useful references
available with data from adults?
Thank you.

Bart Remmerie
Clinical Pharmacology
Janssen Research & Development

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On 23 Jan 2013 at 15:12:56, venkataranganna (m.v.venkataranganna.aaa.connexios.com) sent the message


The following message was posted to: PharmPK

Dear Bart
Both the hemoglobin and the hematocrit are based on whole blood and are
therefore dependent on plasma volume. Venous and capillary blood will
have
similar haemotocrit values. Ofcourse finger manipulation may causes the
expression of tissue fluids and may result in a falsely low hematocrit.
Regards

Venkataranganna M.V., M.Ph, PhD
Connexios Life Sciences

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