PharmPK Discussion - Cortisone concentration in rat plasma

• On 26 Dec 2013 at 09:56:07, wangjian (wj801126.aaa.HOTMAIL.COM) sent the message
  

  
  Dear All,
  
  Does anyone know the concentration of cortisone in SD rat circulating system?  I know the plasma
  concentration of cortisone in human is very low and constant (around 20~30 ng/mL), but I cannot find
  any references about cortisone in rat plasma.  It will be very appreciated that someone can show me
  the data with references.  Many thanks!
  
  Best,
  
  Jian
  
  

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• On 27 Dec 2013 at 09:55:42, Keith Dredge (keithd.aaa.progen-pharma.com) sent the message
  

  
  Long time since I checked but back in my PhD days, we measured corticosterone (not cortisol) as a
  stress hormone because rats do not produce cortisol. There should be plenty of references for
  corticosterone in the literature but not sure if method results in significant variations in basal
  levels. We used an old fluorescence method using serum and lower range was 10-20 ug/dL.
  Keith
  
  

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• On 31 Dec 2013 at 09:58:14, wangjian (wj801126.-at-.hotmail.com) sent the message
  

  
  Dear Keith,
  
  Thanks for your response.  It seems that both cortisone and cortisol are absent in rat.
  
  Jian
  
  

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