PharmPK Discussion - Data formatting in NONMEM

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On 18 Sep 2013 at 10:42:07, Jeran Trangle (Jeran.Trangle.-a-.libd.org) sent the message


Hello,

I have a question while formatting data to run in NONMEM.  I have a single-dosing event record and
want to know what values to record in the interdosing interval "II" field and steady-state "SS"
fields.  I'm familiar with how to log data from pt’s who regularly take a dose (bid, qhs, etc) but
not a one-time dose.

For example -  if a subject takes a .5mg dose at 0800 and their blood is drawn at 1200 I would have:

                #ID     TIME    AMT     RATE    SS      II      MDV     DV      CMT
Dosing Event    1234    0       500     0       ???     ???     1       .       1
Blood Draw      1234    4               0       0       0       0       0.8     2

Thank you,
Jeran Trangle
Jeran.trangle.aaa.libd.org

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On 18 Sep 2013 at 12:33:06, Ahmed Suleiman (ahmed_bisso.aaa.hotmail.com) sent the message


Dear Jeran,

You don't need both columns for a single-dosing event.

You may check NONMEM's Users Guide, Part V, Chapter 6, Section 8.2 for more information on setting
the dosing events.

Best Regards,

Ahmed Abbas Suleiman, MSc
PhD Candidate at Bonn University
Institute of Pharmacology - Clinical Pharmacology Unit
Hospital of the University of Cologne
Gleueler Str. 24, 50931 Cologne,
Germany

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On 18 Sep 2013 at 12:42:27, Soujanya.Sunkaraneni.-at-.sunovion.com sent the message


Hi Jeran,
I agree with Ahmed.
You do not need  SS, II if it is one single dose event. If you have repeated dosing events (for e.g.
QD, BID) then you need those two variables.
Thanks,
Soujanya

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