PharmPK Discussion - Determination of Half life of topical formulation

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On 11 Jan 2013 at 17:12:05, Prashant Musmade (pmusmade.-at-.gmail.com) sent the message


Dear All
We had the micronized formulation of drug which is used for topical
application. Due to micronized form it may reach to dipper part of the
skin and it may absorb to blood. We want determine the half life of this
drug.
Can any one explain how to determin the half life (t1/2) for topical
formulation?
Thanking you

PRASHANT B MUSMADE

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On 11 Jan 2013 at 15:53:08, William Wolowich (wwolowic.-at-.nova.edu) sent the message


The following message was posted to: PharmPK

Prashant:
The "t1/2" of a drug is not dependent on route of administration. t1/2 0.693/ke which is actually =  0.693 * V / CL.
You may be confusing "absorption time" with elimination half-life.

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