PharmPK Discussion - Dose dependent PK and dose normalized C initial

• On 6 Feb 2013 at 14:47:28, W Yiu Kan (wyiukan.at.gmail.com) sent the message
  

  
  Dear all,
  
  I am dealing with a drug candidate that demonstrates dose dependent PK
  properties (the AUC increases non-proportionally with the dosage). This
  drug requires the use of CremophorEL as surfactant and demonstrates a 2
  compartment behavior. The dose normalized plasma concentration profile
  reveals that the Cinitial of this compound following IV administration,
  surprisingly, is dose dependent as well. Has anyone encounter drug
  candidates like this?
  
  The plasma profile has been analyzed by non-compartmental analysis. Are
  there any recommendations for software on PK compartmental analysis? Is
  it necessary to conduct compartmental analysis or modelling for
  preclinical stages?
  
  Thanks in advance.
  Regards,
  Yiu
  
  [Various PK software can be found at http://www.pharmpk.com/soft.html
  C_initial dose normalized or the 'raw' C_initial? - db]
  
  

  Back to the Top

Copyright 1995-2014 David W. A. Bourne (david@boomer.org)