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I am dealing with a drug candidate that demonstrates dose dependent PK
properties (the AUC increases non-proportionally with the dosage). This
drug requires the use of CremophorEL as surfactant and demonstrates a 2
compartment behavior. The dose normalized plasma concentration profile
reveals that the Cinitial of this compound following IV administration,
surprisingly, is dose dependent as well. Has anyone encounter drug
candidates like this?
The plasma profile has been analyzed by non-compartmental analysis. Are
there any recommendations for software on PK compartmental analysis? Is
it necessary to conduct compartmental analysis or modelling for
Thanks in advance.
[Various PK software can be found at http://www.pharmpk.com/soft.html
C_initial dose normalized or the 'raw' C_initial? - db]
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