PharmPK Discussion - Dose translation from one species to other species

• On 6 Feb 2013 at 06:12:58, S Vijaykumar (VijaykumarS.-at-.DRILS.ORG) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear all
  
  Can anybody suggest me how to calculate amount to be dosed in zebra fish
  from rat dose.
  
  VijayKumar.S
  Dr.Reddy's institute of life sciences
  University Of Hyderabad
  
  

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• On 7 Feb 2013 at 13:08:12, David Bourne (bourne5321.-a-.me.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi,
  
  "Can anybody suggest me how to calculate amount to be dosed in zebra
  fish from rat dose."
  
  The size differences in maintenance dose rate (MDR) can be accounted for
  using:
  
  MDRFish=MDRRat*(WeightFish/WeightRat)^(3/4)
  
  Note that this only accounts for the size differences and not for
  species differences in drug elimination.
  
  Nick
  
  

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• On 7 Feb 2013 at 17:14:05, Joachim Grevel (jgrevel.at.btconnect.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear VijayKumar,
  
  Take the volume of distribution from the rat and the volume of your fish
  tank, and multiply the dose accordingly.
  
  Take same safety measure as this is rough and dirty.
  
  Good luck,
  Joachim
  
  

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