PharmPK Discussion - Effect of Food and EHC (Enterohepatic circulation) on Tmax

• On 23 Sep 2013 at 12:31:19, ack G. Shi (JShi.-a-.incyte.com) sent the message
  

  
  Hello all,
  
  Food effect from a high-fat meal typically delays stomach empting and Tmax by 1-2 hrs for most
  drugs, but I am wondering if there are published papers (reviews, individual compounds, M&S) looking
  at food effect on Tmax for drugs that undergo EHC.  Intuitively, food intake could trigger EHC and
  should further prolong Tmax.  What is your experience?
  
  Thanks,
  Jack
  
  

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• On 24 Sep 2013 at 13:30:52, mamoun zoubi (mamoun78_a.-at-.yahoo.com) sent the message
  

  
  Hello all
  you can look for clopidogrel  and their metabolite as example
  thanks
  
  

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• On 25 Sep 2013 at 09:05:24, Jack G. Shi (JShi.at.incyte.com) sent the message
  

  
  I don't think clopidogrel is a good example as the drug itself does not undergo EHC but thanks for
  mentioning it.  Diclofenac or rofecoxib are more interesting molecules (for this ADME feature), but
  since most food effect studies are conducted with a single dose, a significant influence on Tmax by
  EHC perhaps is not to be expected.  In my case, the food study was conducted at PK steady-state.  I
  have other evidence to support EHC for the drug, but not sure if I should relate a food induced
  4-hour Tmax increase to it.  Tx.
  
  

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