PharmPK Discussion - Fraction of drug dissolved

• On 17 Apr 2013 at 22:01:59, Chandramouli Radhakrishnan (moulirc.at.hotmail.com) sent the message
  

  
  Can some body tell me how i can calculate fraction of drug dissolved in dissolution
  testing.
  i was thinking it's the percentage dissolved at a particular time.  Am i right?
  
  kind regards
  moulirc.-a-.hotmail.com
  

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• On 17 Apr 2013 at 15:30:34, Lawrence Block (lhblockphd.aaa.gmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  The fraction dissolved is based on the total amount of drug dissolved
  relative to the total amount of drug in the dosage form. Please keep in
  mind that the total amount of drug is based on actual assay results for
  a representative sample of the dosage form, not on the "labeled" amount
  of drug in the dosage form. The latter, I.e. labeled amount, could
  differ substantially from the actual amount.
  
  Also, be careful about the time period on which the calculation is
  based. Is it from t = 0 to time = t, or is a specific time increment?
  
  Lawrence H. Block, Ph.D.
  Emeritus Professor of Pharmaceutics
  Duquesne University
  
  

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• On 17 Apr 2013 at 16:51:12, Stanley Cotler (msgcot2.at.optimum.net) sent the message
  

  
  The following message was posted to: PharmPK
  
  I would draw up a sample, with a syringe and pass it through a Millipore filter
  and analyze the effluent.
                                   Stanley Cotler
  

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• On 17 Apr 2013 at 19:42:09, (Ttarnowski1.-a-.aol.com) sent the message
  

  
  Alternatively, an aliquot of the total sample could be withdrawn by pipette and
  centrifuged in a temperature-controlled centrifuge (same setting as the
  dissolution apparatus), and analyze the supernatant.  This assumes that the
  analyte has a higher density than the solvent.
  
  -Tom
  
  Thomas L. Tarnowski, Ph.D.
  Corporate Liaison & Special Tasks Director
  Organizing Committee
  CACO Pharmaceutical and BioScience Society
  thomas.tarnowski.at.pbss.org
  ttarnowski1.at.aol.com
  www.pbss.org
  
  

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• On 18 Apr 2013 at 07:22:05, "Prof. Dr. Zafar Iqbal" (zafar_iqbal.at.upesh.edu.pk) sent the message
  

  
  Dear colleague,
  
  Take the samples periodically and withdraw last sample when dosage form
  completely dissolved. Then analyze and calculate fraction of the drug
  dissolved at each time interval.
  
  Dr Zafar
  
  

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