PharmPK Discussion - in-vivo P-gp inhibitor

• On 1 Jun 2013 at 22:31:43, hanliang0705 (hanliang0705.-a-.163.com) sent the message
  

  
  Dear all,
  
  I would like to explore a PK study using the P-gp efflux blocker (such
  as
  GF120918, Elacridar) to increase the F% of a drug. While for the in-vivo
  studies, which blockers can be used in dog PK studies and what are the
  dose
  levels? You will be appreaciated if you have any inputs or literatures.
  Thanks,
  Jack
  
  [First message from Colorado if this gets to you (all) - db]
  
  

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• On 3 Jun 2013 at 07:23:49, Prashant Musmade (pmusmade.aaa.gmail.com) sent the message
  

  
  Dear Jack
  
  You can refer to
  http://www.fda.gov/downloads/Drugs/
  GuidanceComplianceRegulatoryInformation/Guidances/UCM292362.pdf
  You can get the inhibitor for P-gp for in vivo study you can convert the
  human
  dose to animal dose. It will be good if you do it in minimum three doses
  of inhibitor. I used Verapamil in rats as P-gp inhibitor.
  
  Thanking you
  
  

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