PharmPK Discussion - Plasma volume in children

• On 13 Feb 2013 at 09:49:28, "Charlie Brindley " (charlie.brindley.aaa.kinetassist.com) sent the message
  

  
  We have found a statistically significant 40% increase in Vss in children
  compared to adults for a large molecular weight compound.
  
  Including BMI in the statistical model reduced the difference to 28%.
  
  The geometric mean values of Vss are 64.2 and 89.6 mL/kg in adults and children
  respectively.
  
  Notwithstanding the small difference, could it be explained in part by a
  relatively larger plasma volume in children?
  
  Any references for a smaller plasma volume in children?
  
  Thanks
  
  Charlie Brindley
  
  

  Back to the Top

• On 13 Feb 2013 at 07:12:26, "Michael B. Bolger" (bolger.aaa.simulations-plus.com) sent the message
  

  
  Charlie, blood volume in infants and children as a percent of body weight is
  larger (~12%) than in adults but the CV% of the measurement is ~10%. Pediatric
  and adult population simulations in GastroPlus(TM) utilize equations for
  blood
  volume that include body weight and height for any age from birth to 85
  yo.
  Naturally, the physicochemical and biopharmaceutical properties of your
  molecule
  play a large role in estimation of Vss for PBPK models prior to in vivo
  testing.
  
  Ref. Linderkamp O., Eur. J. Pediat., 125:227 (1977)
  
  Mike
  
  Michael B. Bolger, Ph.D.
  Chief Scientist
  

  Back to the Top

Copyright 1995-2014 David W. A. Bourne (david@boomer.org)