PharmPK Discussion - Pop-PK model of Digoxin

• On 23 Jan 2013 at 16:16:20, "Nalda Molina, Jose Ricardo" (jnalda.aaa.umh.es) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Members,
  
  We are trying to perform montecarlo simulations of PK profiles of
  digoxin in  Caucasian population. However,  the only Pop-PK model in
  this population that I've found so far is the one described by Hornestam
  et  al (cited below). This model has several limitations: Main
  limitations are they could not estimate IIV in central volume,
  peripheral volume and Inter-compartmental Clearance, probably due to its
  limited data
  sampling, as they point out in the paper. Another question is that
  weight does not appear as a covariate in Cl, when in all the models that
  I've seen so far, weight is always a covariate, not only
  of Cl, but also of Volumes and Inter-compartmental Clearance. So my
  question is, whether there is, to the best knowledge of the members, any
  other pop-PK model of digoxin in Caucasian population, to
  the one mentioned above?
  
  Thanks in advance,
  
  Ricardo Nalda-Molina
  
  University of Miguel Hernandez,
  Pharmacy and Pharmaceutics Division, Department of Engineering, School
  of Pharmacy
  Alicante (Spain).
  
  

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• On 23 Jan 2013 at 12:16:11, Ahmed N Mohamed (ammohame.at.purdue.edu) sent the message
  

  
  Ricardo,
  
  Here is another one in Japanese patients.
  
  Clin Pharmacokinet 2001; 40 (10): 773-781
  
  It has TBW as a covariate on CL, V1, V2, and Q. Hope it's useful.
  
  

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