PharmPK Discussion - Reference books on selection of optimal sampling time

• On 26 Mar 2013 at 12:02:35, claire ong (claireong899.aaa.gmail.com) sent the message
  

  
  Dear All,
  
  I'm a novice at PK PD modeling and is currently trying to plan an
  experiment for PK analysis. May I check if anyone know of any good
  reference books or websites that I can refer to that provide insight
  into optimal blood sampling times?
  
  thanks
  Claire
  
  

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• On 26 Mar 2013 at 20:57:24, Coen van Hasselt (coenvanhasselt.-a-.gmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi Claire,
  
  You might consider to use optimal design methodology to derive
  informative study design characteristics, such as when to take PK
  samples (but maybe also other design characteristics), based on your
  prior expectations about the PK.
  
  These two papers might be useful in better understanding some concepts
  and techniques related to the informative design of PK studies (even
  if you are not going to look into optimal design stuff further):
  Duffull et al. Clin Exp Pharmacol Physiol. 2001 Nov;28(11):905-12.
  Duffull et al. J Pharmacokinet Pharmacodyn. 2005 Aug;32(3-4):441-57.
  
  You might play around with some of the available optimal design
  software packages freely available online such as WinPOPT, PopED, or
  PFIM, which also include a graphical user interface.
  
  I think that, in my experience at least, simply combining knowledge of
  what is already known about the PK with the use of some of your common
  sense already gets you quite far in determining what would be at least
  reasonably informative sampling times.
  
  Best regards,
  Coen
  
  

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• On 26 Mar 2013 at 20:26:14, Stephen Duffull (stephen.duffull.at.otago.ac.nz) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi Claire
  
  It really depends on what you want to do and your background as to where
  you will want to start on this.
  
  You can join the Popdesign email listserver which will put you in touch
  with people from around the globe who struggle with this question:
  http://lists.otago.ac.nz/listinfo/popdesign
  
  The following general texts have chapters on optimal design:
  Kimko & Duffull. Simulation for Designing Clinical Trials, Marcel Dekker
  Bonate. Pharmacokinetic-Pharmacodynamic Modeling and Simulation,
  Springer.
  
  If you have a statistical background then:
  Atkinson & Donev. Optimum Experimental Design. Clarendon Press.
  
  Otherwise there are a number of references on population optimal design
  which have been published.
  
  Regards
  
  Steve
  --
  Professor Stephen Duffull
  Chair of Clinical Pharmacy
  School of Pharmacy
  University of Otago
  PO Box 56 Dunedin
  New Zealand
  E: stephen.duffull.at.otago.ac.nz
  
  

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