PharmPK Discussion - Retro-orbital vs. tail vein dosing Mouse PK

• On 6 Aug 2013 at 15:27:51, timwchow.aaa.GMAIL.COM sent the message
  

  
  Hi everyone,
  
  I'm interested in doing a mouse PK study in some rather small black mice. For systemic dosing, I had
  planned to dose via the tail vein, but identifying the tail vein has been difficult. I'm looking
  into doing retro-orbital dosing in these mice, but wonder if these two routes of administration are
  comparable. Does anyone have any information on the comparability of retro-orbital versus tail vein
  dosing in mice?
  
  Cheers,
  Tim
  
  

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• On 7 Aug 2013 at 20:46:59, Varun Khurana sent the message
  

  
  Hello Tim,
  
  You can find many publications where it has been reported that both the routes are similarly
  effective. No biologically significant differences in terms of organ/tissue ditribution were found
  between tail vein and retro-orbital routes of injection. The only advantage retro-orbital injection
  has, that they are considered less stressfull and more humane in comparison to tail vein or other
  intravascular injections in mice. Both routes are equally effective and can be adimistered
  interchangeably.
  
  Thanks and Regards
  Varun Khurana
  
  

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