PharmPK Discussion - Timescaling IVIVC

• On 10 Aug 2013 at 00:12:38, Harish Kaushik Kotakonda sent the message
  

  
  Hello,
  I have a basic question in IVIVC
  I have a drug's dissolution data collcted at certain time points and I also have Invivo plasma
  concentrations measured at different time points to that of dissolution time points.
  If i have to build IVIVC i know i have to perform Time scaling, Can anyone explain me how to do
  timescaling
  
  Regards
  Kaushik
  
  [You might look at: LEVY, G., Leonards, J., & Procknal, J. (1965). Developement of in vitro
  dissolution tests which correlate quantitatively with dissolution rate limited drug absorption in
  man. Journal of Pharmaceutical Sciences, 54(12)(12), 1719–1722. doi:10.1002/jps.2600541204 - db]
  
  

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• On 10 Aug 2013 at 22:06:40, Leonid Gibiansky sent the message
  

  
  Hi Kaushik,
  Conceptually this is not very difficult. You fit some function f(t) to
  the dissolution curve, and then look for the function F(f(a0+a1*t)) that
  would describe in-vivo dissolution (a0 is delay, a1 is the time scale).
  Implementation could be tricky. WinNonlin has it implemented as add-on,
  as well as GastroPlus. Or you can do it in Nonmem (or other modeling
  software), see
  
  A comparison of the prediction accuracy of two IVIVC modelling
  techniques Clare Gaynor, Adrian Dunne, John Davis DOI: 10.1002/jps.21220
  
  or other works by Adrian Dunne and co-authors
  
  Leonid
  
  --
  Leonid Gibiansky, Ph.D.
  QuantPharm LLC
  
  

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