PharmPK Discussion - Tlag in 2 and 3 compartment oral model

• On 27 Dec 2013 at 15:12:26, Harish Kaushik Kotakonda (kaushikkotakonda.at.GMAIL.COM) sent the message
  

  
  Hello All,
  I have few questions which are basic and about which iam curious to know , my question's are
  
  1. How do we graphically determine lag time (Tlag) in 2 compartment and 3 compartment oral models
  while fitting PCT data generated after oral administration ?
  
  Most of the Textbooks deal about Tlag estimation (graphical) in 1 compartment oral model cases but
  not in higher compartment model cases
  
  2. Does Tlag estimate seriously impact the final estimation process in Nonlinear regression of the
  PCT data in case of 2 & 3 compartment models
  
  Thanks for all your help
  
  Regards
  Kaushik
  
  

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• On 27 Dec 2013 at 11:16:27, Nathan Teuscher (nathan.at.learnpkpd.com) sent the message
  

  
  Kaushik,
  
  The lag time is a delay between dose administration and absorption of the drug into the systemic
  circulation. Tlag can be included as parameter in any model. If you take a standard 2 compartment or
  3 compartment model and replace instances of time (t) with the expression (t-tlag), you can then
  estimate the parameter tlag.
  
  The inclusion of Tlag is important to accurately characterize the pharmacokinetics of a drug where
  there is a lag between dose administration and drug absorption.
  
  Best of luck!
  Nathan Teuscher
  --
  Nathan S. Teuscher, PhD
  Founder and President, PK/PD Associates
  
  

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