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Dear PharmPK users:
I would like to enquire with the group about the decision making process
in included or not a turbidimetric method to determine MIC in human
serum for antibacterial compounds and its utility to predict the
antimicrobial activity in-vivo.
It's well known that in most of the cases free drug concentration
affects pharmacological activity, and this fact is well described in the
case of some antibiotics. However, this fact can be misleading because
PPB has different effects for in vitro and in vivo systems, and so high
PPB and low potency on addition of serum in the assay do not necessarily
translate to poor in vivo efficacy.
PPB in vivo occur dynamically and simultaneously which is different to
the in vitro environment, which is static.
Hope you can give me your experiences Very best regards
Javier Alejandro Estevez Gomez; PharmD (jestevez at ferrergrupo.com)
Pharmacokinetic & Pharmacodynamic Modeling and Simulation FERRER
INTERNATIONAL SA. Early Development Center Joan XXIII, 10 08950
Esplugues de Llobregat, Barcelona Spain
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