PharmPK Discussion - Winnonlin graphing question

• On 10 Jan 2013 at 16:01:40, Hao Pan (haopan.-a-.gmail.com) sent the message
  

  
  Hi,
  
  Please see the graph made by Winnonlin in the link below. It is a simple
  Emax PD model fitting. Does anyone know why the predicted curve (blue
  line) wouldn't extend to the left area where some observed data exist
  (green circled area)?
  
  https://picasaweb.google.com/haopan/January102013#5831927047580156994
  
  Tried graphing setting in Winnonlin but no luck yet.
  
  Thanks for any suggestions.
  
  Hao
  
  [Strange place for it to stop. I could see it not wanting to cross zero?
  - db]
  

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• On 10 Jan 2013 at 16:44:28, Baiteng Zhao (baitengzhao.aaa.yahoo.com) sent the message
  

  
  Hi Hao,
  
  Does the predicted curve extend to zero when you plot with linear
  x-axis? If it does, the artifact in the log plot might be due to the
  step size of the concentration in your prediction being greater that the
  first few concentrations in the dataset. You may try to increase the
  number of predicted values (i.e. reducing the step size) and see whether
  it helps. Good luck.
  
  BZ
  
  

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