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I want to run several data-sets in batch mode within WinSAAM. I tried
just concatenating two data-sets as a test. (The file "TestBatch.saam"
can be viewed at http://cvm.msstate.edu/~langston/download/ .) It seems
to recognize that two decks exist, but only solves for the first deck.
(See file "BatchSAAM Output Langston.pdf" also at the same site.)
What do I need to do to get WinSAAM to run each deck while in batch
mode?
Thanks in advance,
Cory Langston
--
Cory Langston, DVM, PhD, DACVCP
College of Veterinary Medicine
240 Wise Center Drive
Mississippi State, MS 39762-6100
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The following message was posted to: PharmPK
(I know that Ray Boston reads the list so he may jump in)
If you have the examples from the book (Wastney et al.) then
CH13EG1.SAAM is a good template for this. Key differences from a single
subject script are; (1) make sure you specify a variability model (e.g.
an FSD entry in the lines in the DAT section) and (2) the "A SAAM31"
line is interpreted much more strictly and requires you to have a
project identifier code, the study/subject number and the project name
(all in thir appropriate field locations). If you are using the
Population option within WinSAAM to read in the individual files, it
will take care of the second header line ('2') for you with the number
of iterations and the model code (19 and 20).
Check the contents of the output file (if you see "NO PROBS IN DECK"
there was something wrong).
All the very best,
Bernard
Bernard Murray, Ph.D.
Senior Research Scientist, Drug Metabolism,
Gilead Sciences
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Hello Cory,
The model file I mentioned was included on the CDROM with the book but wasn't
listed in the text. Below are two very simple model files with data with random
noise. Take the text (using a fixed-width font) from the 'A SAAM31' line to the
'C End of Deck' line and save them cleanly in separate .saam model files
(ideally then check them by pulling them in to the WinSAAM text editor to check
the data are in the correct fields). Open WinSAAM and go to Project/New.
Indicate that it is a Population Study and Attach the two .saam files you
created, one after the other. Then press Run. You should get a 'WS SAAM
Output' window with the textual output of the individual runs for the two model
files, and the population analysis at the bottom (also stored in projout.txt).
The 'Project Output' workbook will have the Parameter summary. The combined
model file will be in assemble.txt.
As I mentioned earlier. The 'A SAAM31' line is interpreted strictly so
make
sure that all the model files for the subjects have the same project name but
different subject names.
I hope that this helps. Good luck!
All the very best,
Bernard
Bernard Murray, Ph.D.
Senior Research Scientist, Drug Metabolism,
Gilead Sciences, Foster City CA
A SAAM31 IVB001.001 ADEMO001
2 25 19
C Bolus dose to one compartment with linear elimination
H PAR
C Parameters are as follows
C P(1) Dose in mg
C P(2) Volume in L
C P(3) Clearance in L/hr
P(1) 100
C Initial Minimum Maximum
P(2) 50 5 500
P(3) 7 0.7 70
C Central compartment is 1 and concentration is in mg/L
IC(1) = P(1)/P(2)
C Linear elimination from central compartment (to 0 from 1)
L(0,1) = P(3)/P(2)
C Convert mg/L to ng/mL to match observed
K(1) = 1000
H DAT
C Store in location 1
101F(1) FSD=.2
C Time (hr) Concentration (ng/mL)
0 6026.4
0.1 5933.3
0.25 6087.7
0.5 4914.9
1 4980.0
2 3851.7
3 3134.6
4 2357.6
6 1553.2
8 938.9
12 371.6
16 132.4
24 20.6
C End of Deck 1
A SAAM31 IVB001.002 ADEMO001
2 25 20
C Bolus dose to one compartment with linear elimination
H PAR
C Parameters are as follows
C P(1) Dose in mg
C P(2) Volume in L
C P(3) Clearance in L/hr
P(1) 100
C Initial Minimum Maximum
P(2) 50 5 500
P(3) 7 0.7 70
C Central compartment is 1 and concentration is in mg/L
IC(1) = P(1)/P(2)
C Linear elimination from central compartment (to 0 from 1)
L(0,1) = P(3)/P(2)
C Convert mg/L to ng/mL to match observed
K(1) = 1000
H DAT
C Store in location 1
101F(1) FSD=.2
C Time (hr) Concentration (ng/mL)
0 2376.0
0.1 2333.9
0.25 2382.7
0.5 2033.9
1 2090.4
2 2011.5
3 1955.7
4 1899.9
6 1574.5
8 1441.0
12 1122.7
16 869.8
24 530.1
C End of Deck 2
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