Hello all.Back to the Top
I' m looking for a piece of software able to calculate AUC surface
(area under the curve), or MDT (Mean dissolution time).
Actually, I'm working with drug in vitro dissolution data (concentration &
time).
The best I could expect, is some software for the AUC calculation,
regardless of
the dissolution kineticks profile, but I quess any program being able to
calculate
AUC using two sets of data should do.
I've already tried the PRISM shareware, but it seems that for some unknown
to me reason, the calculation method it uses, provides "mysterious"
results, compatible only with PPG (pragmatic plane geometry), not in
compliance with the graphical determination method, which should be the
reference value.
Any recommendations will be much appreciated.
Thank you.
[db - Boomer at http://www.boomer.org/ will do this but may be more
complicated than needed - others may have developed Excel spreadsheets to
do this calculations - there is a list of PK software at
http://www.cpb.uokhsc.edu/pkin/soft.html - if anyone knows of software not
on this list that could be added please let me know
mail:david.at.pharm.cpb.uokhsc.edu - other responses might be directed to
Nikos directly - thanks]
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[Two replies - db]
Date: Thu, 06 Aug 1998 15:10:53 -0400
From: "Boyd Newlin"
Organization: PPD Pharmaco, Inc.
MIME-Version: 1.0
To: PharmPK.aaa.pharm.cpb.uokhsc.edu
Subject: Re: PharmPK Software search
Have you tried Win-nonlin?
++
| Boyd M. Newlin |
| PPD Pharmaco, Inc. |
| Pharmacokinetics |
| boyd.newlin.at.richmond.ppdi.com |
| Phone: (804)359-1390 x5036 |
| Fax: (804) 359-1591 |
++
---
Date: Fri, 7 Aug 1998 11:15:52 +0200 (MET DST)
From: Maria Durisova
To: PharmPK.-a-.pharm.cpb.uokhsc.edu
Subject: PharmPK Software search
Our study:
DURISOVA, M., DEDIK, L.: Modeling in frequency domain used
for assessment of in vivo dissolution profile.
Pharmaceutical Research, 14, 1997, 860-864,
describes application of our software package CXT (a version
of it is available at PharmPK) in modeling drug dissolution
profiles. The procedure presented in this work is
model-dependent and methodically uniform, using exclusively
concepts of the theory of linear dynamic system.
It can be used also for modeling in vivo cumulative drug absorption
profiles. It is is not restricted to a special form of drug
kinetics. In the work, also a criterion was proposed and
applied in evaluating similarity of two dissolution profiles.
Best regards,
Maria Durisova
and
Ladislav Dedik
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Dear Nikos and others,
I have written NCOMP, a program for noncompartmental analysis of PK data, which
will get you an AUC as well as other parameters. NCOMP is distributed by me
free
of charge preferably by email (plaub.at.incyte.com), as I have to pay the postage
out of pocket. NCOMP is a Windows 3.1/95/NT executable and is best used with a
spreadsheet program like Excel 5.0 or higher. The program is formally described
in --
PB Laub and JM Gallo
NCOMP - A Windows-based Computer Program for Noncompartmental Analysis of
Pharmacokinetic Data
J Pharm Sci 85: 393-395 (1996)
Let me know if you would like a copy.
Paul Laub
--
Paul B. Laub Incyte Pharmaceuticals 3174 Porter Dr. Palo Alto, CA 94304
(650) 845-5411 (voice) plaub.aaa.incyte.com (650) 855-0572 (fax)
Back to the Top
[A few replies - db]
X-Sender: dfarrier.-at-.mail.bright.net
Date: Sat, 08 Aug 1998 00:35:18 -0700
To: PharmPK.at.pharm.cpb.uokhsc.edu
From: "David S. Farrier"
Subject: Re: PharmPK Software search
Mime-Version: 1.0
Dear Nikos,
"PK Solutions 2.0" is an Excel-based program that will not only calculate
AUC for any time-concentration data set, but will also instantly tabulate
and graph some 75 additional noncompartmental PK blood level parameters
using both AUC (graphical) and exponential terms as the basis for
computation. The application is easy, interactive, and comprehensive and is
used in pharmacy schools and research labs around the world. A free demo
and a free compilation of the noncompartmental PK equations can be obtained
from the following site:
http://www.bright.net/~dfarrier
Regards,
David
David S. Farrier, Ph.D.
Summit Research Services
1374 Hillcrest Drive
Ashland, OH 44805 USA
Telephone: (419)-289-9207
E-mail: dfarrier.aaa.bright.net
Internet: http://www.bright.net/~dfarrier
---
X-Sender: peterb.aaa.cherwell.com
Date: Mon, 10 Aug 1998 11:00:15 +0100
To: PharmPK.aaa.pharm.cpb.uokhsc.edu,david.at.pharm.cpb.uokhsc.edu,
npapail.-at-.otenet.gr
From: Peter Bispham
Subject: PharmPK Software search
Mime-Version: 1.0
I can recommend our numerical modelling package, ModelMaker. This has been
demonstrated as being able to successfully calculate AUC (including the sum
to infinity AUC). It can also handle multiple sets of data.
In addition, ModelMaker has extensive calculation abilities and can easily
calculate properties such as dissolution time, half life etc.
If you need further information on ModelMaker, look at:
http://www.cherwell.com/modelmaker/index.html
Many ModelMaker examples are included on the page:
http://www.cherwell.com/modelmaker/mm-examples.html
Demo software can be downloaded from the page:
http://www.cherwell.com/support/demodown.html
Peter Bispham
Dr Peter Bispham Ph.D. C.Phys. | email: peter.bispham.-at-.cherwell.com
Technical Consultant | Phone: +44 (0)1865 784812
Cherwell Scientific Publishing | Fax: +44 (0)1865 784801
Oxford OX4 4GA, UK | URL: http://www.cherwell.com
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)