PharmPK Discussion List Archive - 1998

PharmPK Discussion List Frequently Discussed Topics

4-OH Debrisoquine Plasma Concentrations in Normal Metabolisers after 10mg
5 fluoro-uracil extraction in plasma
A design question
Abciximab: A problem in pharmacodynamic modeling
Absolute bioavailability
Accumulation of Radioactivity in Stomach
Acetaminophen toxicity in children
ADAPT II - Practical Help
Alcohol absorption, GI Motility and or CYP2D6 Metabolism of Codeine
Aminoglycoside OD
ANOVA for comparison of bioavailabilities
Antibiotic concentrations in the lung
Anticoagulants
Apparent Bioavailability in Excess of 100%
ARSAC calculations
Assignment to groups using 2+ Variables
AUC/MDT Software
Balanced Clearance
Bathochromic effect
Bayesian Forecasting programs
Bile Flow Rate in Mice
Bioavailability determination
Bioavailability question
Biodistribution study
Bioequivalence ANOVA?
Biotransform
Body mass problem in bioequivalence study
Brattelboro Rat or the Borderline hypertensive rat
Breaking emulsion
Buccal absorption
CaCo-2 cells
Calcitriol PK
CD4+ Turnover rate
Ceftazidime and CVVH
Clearance of phenytoin
Clin Pharm 2.0
Clinical Research
Concentration/Effect and metabolites
Concentrations in biofluids
Controlled release PK
Controlled-release preparations
Cost X benefit
Coworker in the field of bioequivalence
CVVH
CYP450 interactions
CYP450 isozyme
Deconvolution Programs
Development of a cell-based assay for drug screening
Dexamethasone
Dextrorphan powder
Different IV and oral doses for Cefuroxine
Displacement from protein binding
Distribution Equilibrium References
Distribution of naratriptan and zolmitriptan
Dose for Linearity/Non-Linearity
Dosing in children
Drugs having sigmoid curve
Dynamic models
Endotoxin Measurement
Enzyme Inhibitor
Equations of conc. vs time for non-linear kinetics
Erythromycin
Esterase Distribution
Estimating bioavailability of a drug that must be hydrolyzed prior to being active
Ethamsylate Pharmacokinetics
Evaluating PK and PD Trials
Fatty acid pharmacokinetics
First Dose in Man
Free Iodine
Fuzzy logic modelling
Gabapentin
Ganite
GI Motility and CYP2D6 Metabolism of Codeine
Guaifenesin
Half-Life of Bicuculline
Half-life of drug elimination
Handbook of Pharmacokinetics
Hard water - tetracycline Interaction?
Home grown kinetics
Human bile
IBW Calculations
Illustrations
Induction rate and induction factor in Abbottbase
Insulin PK/PD
Inteference presence
interaction between tramadol and muscle relaxants.
Inulin determination in body fluid
ISO regulations
IV and PO data with different 'number' of compartments
IV placement unit
IV solvent
Ketoprofen enantiomers
Kinetica 2.0 Release
Kinetica PKPD Software FREE for Students
Kintool
Labs performing in vitro metabolism studies
Lisinopril measurement
List of PK data
Local anaesthetic/opioid mixture stability
Looking for basic pharmacokinetic parameters
Looking for evaluator
Losartan+icatibant
Lowest antiplatelet dose of aspirin
Manufacturing question
Maximum infusion rate / volume for rat PK/PD studies
Mecamylamine
Mecamylamine assay
Medical software in Spanish?
Metabolism of troglitazone
Metabolite Question
Metallothioneins
Methotrexate
Methotrexate via Ommaya
Metronidazole rectal
Modelling of lidocaine pharmacokinetics
Molecular size and breastfeeding?
Monoacetyl dapsone
Nalbuphine Assays
Nanoparticle study
Need for albendazole-sulphoxide
Nicotine-Cotinine assay
Non-compartmental analysis
Non-heparin anticoagulation
NPEM question
P-aminophenyl-alpha-D-Mannopyranoside resin
Parallel Design
PBPK Software
PCNonlin, WinNonLin, PK/PD book
Pharmacodynamics Question
Pharmacodynamics: Children vs. Adults
Pharmacokinetics of 3,4 diaminopyridine
Pharmacokinetics of 4-chloro-m-cresol
Pharmacokinetics of Lidocaine
Pharmacokinetics of second hand smoke
Phenytoin-Winter/Tozer Adjustments
PK modelling - Kinetica
PK Models on the Web!
PK Software for window 95
PK Study design question
PK-Simulations
PKPD modeling of glucose clamp studies?
Plasma/buffer issue in a clinical study
Population Analysis of Pooled Phase-I Data
Population PK/PD studies
Pre therapy Digoxin levels
Predicting the Profile of Multiple Doses?
Prodrug stability
Propofol/remifentanil on CPB
Protein binding - acidic - interspecies
Protein Binding Question
Prothrombin times
Question Free Iodine
Rat Organ Weights
Reimbursement for PK service
Renal Clearance
Renal clearance of phenytoin
Request for information on microbial metabolism of FQ's
Risperidone, 9-hydroxyrisperidone
Robustness of the Simplex method
Salivary APAP
Sample blood in rats
Sample Size Calculation
Sample Size for intraindividual bioequivalence
Silastic tubing
Simulation software for teaching
Software for ED50/IC50 calculations
Solution or suspension
Solvent
SOP for assaying samples from PK studies
Stability studies
Stomach mice pH
Study design question
Sucralfate/proton pump inhibitors
Sulfate esters
Take with a full glass of water...
Taurine analysis
TDM of psychotropic drugs
The First Annual Meeting on the Experimental Therapeutics for Human Cancer, June 11-13, 1998.
The recent Pharmacokinetic Books
Therapeutic Drug Monitoring of psychotropic drugs
Thrombolytis in acute MI patients
Toxicity of Bile Salts
Toxicity of deoxyinosine as modulating agent of 5-FU activation
Tumor Imaging
Tween 80
Two compartment absorption model
Unexpected toxicity
Urine Clearance Data Set
Use of arbitrary values for plasma levels below LOQ in toxicokinetic studies
Vanco monitoring in IPD
Vancomycin monitoring in ESRD patients
Variable Infusions and Dose Linearity
Vitamin D3 PK
Volume of Distribution
Warfarin dosing
Warfarin pharmacodynamics model
Way of establishing Css
Weighting
WinNonlin
WinNonlin help!

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