PharmPK Discussion - Bioavailability determination

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On 23 Jun 1998 at 10:59:19, David Claghorn (dclaghorn.aaa.ilexonc.com) sent the message


I hope this isn't too elementary, but I can't find anything in my
Applied PK text, how can you calculate bioavailability without an IV
comparator?

Dave Claghorn, Pharm.D.
Assoc. Dir., Medical Affairs
Ilex Oncology

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On 24 Jun 1998 at 10:15:40, Nabil B. Darwazeh (DARWAZN.at.war.wyeth.com) sent the message


you need IV PK to estimate the absolute bioavailability, or you can
estimate the relative bioavailability by comparing to an oral solution or to
a known dosage form.

Nabil Darwazeh

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