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[A couple of replies - db]
From: "Smith, Patrick Pharm.D."
Subject: Re; Concentration/Effect and metabolites
Date: Mon, 23 Nov 1998 18:31:00 -0500
If the concentration-effect is that of toxicity there are many examples,
such things that come to mind include, namely isoniazid, acetaminophen,
, meperidine in renal dysfunction, and other opiates.
If the effect is EFFICACY, I believe itraconazole (hydroxyitraconazole)
is at least as important a measure as is the parent compound. Many of
the antiviral compounds must be converted into the active phosphorylated
form to be active (does that count?). Interesting question, hopefully
others can shed more light
Date: Mon, 23 Nov 98 15:38:55 -0700
From: "Mike Jones"
Subject: Re: PharmPK Pharmacodynamics Question
Derendorf H & Hochhaus G: Handbook of Pharmacokinetic/Pharmacodynamic
Correlation. CRC Press, Inc., Boca Raton, FL. 1995.
Hope this helps,
Mike Jones, Pharm.D.
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