PharmPK Discussion - Concentration/Effect and metabolites

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On 24 Nov 1998 at 14:20:14, David_Bourne (david.aaa.pharm.cpb.uokhsc.edu) sent the message

[A couple of replies - db]

From: "Smith, Patrick Pharm.D." 
To: PharmPK 
Subject: Re; Concentration/Effect and metabolites
Date: Mon, 23 Nov 1998 18:31:00 -0500
MIME-Version: 1.0

If the concentration-effect is that of toxicity there are many examples,
such things that come to mind include, namely isoniazid, acetaminophen,
procainamide , meperidine in renal dysfunction, and other opiates.

If the effect is EFFICACY, I believe itraconazole (hydroxyitraconazole)
is at least as important a measure as is the parent compound.  Many of
the antiviral compounds must be converted into the active phosphorylated
form to be active (does that count?).  Interesting question, hopefully
others can shed more light

patrick smith

---

Date: Mon, 23 Nov 98 15:38:55 -0700
From: "Mike Jones"
To: 
Subject: Re: PharmPK Pharmacodynamics Question
MIME-Version: 1.0

     Bertil,

     Please see:
     Derendorf H & Hochhaus G: Handbook of Pharmacokinetic/Pharmacodynamic
     Correlation. CRC Press, Inc.,  Boca Raton, FL. 1995.

     Hope this helps,

     Mike Jones, Pharm.D.
     Micromedex, Inc.,
     Denver, CO

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