PharmPK Discussion - Displacement from protein binding

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On 1 May 1998 at 10:07:30, Aideen Young (ayoung.-a-.hbase.com) sent the message


Can anyone suggest some key references for the statement that
'displacement from protein binding is an unimportant mechanism for drug
interactions'?

With thanks,
A Young

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On 4 May 1998 at 11:50:49, David_Bourne (david.aaa.pharm.cpb.uokhsc.edu) sent the message

From: Nick Holford 
Sender: nhol004.-a-.auckland.ac.nz
Reply-To: n.holford.-at-.auckland.ac.nz
To: PharmPK.aaa.pharm.cpb.uokhsc.edu
Subject: Re: PharmPK displacement from protein binding
Date: Sat, 2 May 1998 08:56:30 -0400 (Eastern Daylight Time)
Priority: NORMAL
X-Authentication: none
MIME-Version: 1.0

Try "Avery's Drug Treatment" 4th Edition, Adis Intl, 1997 e.g. Chapter 1.

--
Nick Holford, Center for Drug Development Science
Georgetown University, 3900 Reservoir Rd NW, DC 20007-2197
email:n.holford.-a-.auckland.ac.nz tel:(202)687-1618 fax:687-0193
http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.htm

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Date: Mon, 04 May 1998 08:21:02 +0200
From: Hans Markus Bender 
MIME-Version: 1.0
To: PharmPK.-a-.pharm.cpb.uokhsc.edu
Subject: Displacement from protein binding
X-Priority: 3 (Normal)

Hallo Aideen Young,displacement from proteinbinding may be important for
clinical purposes, but only under special circumstances. An article of
P.E.Rolan in the Br.J.Clin.Pharmac. 37 (1994), p.125-128 focuses on the
clinical importance and in a more theoretically view Sansom & Evans in
Drug Safty12(4), 1995, p. 227-233.

H. M.Bender

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X-Sender: smelethil.-at-.cctr.umkc.edu
Date: Mon, 04 May 1998 09:53:58 -0500
To: PharmPK.-at-.pharm.cpb.uokhsc.edu
From: Sri Melethil 
Subject: Re: PharmPK displacement from protein binding
Mime-Version: 1.0

Please refer to  Applied PK by Evans, Schentag and Jusko, (3rd or 4th
edition), Applied Therapeutic Inc., 1992 or later.

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On 5 May 1998 at 09:53:33, "Lockwood, Peter" (Peter.Lockwood.-a-.wl.com) sent the message


Try
Plasma protein binding displacement interactions - why are they still
regarded as clinically important
Rolan P.E. - Br J Clin Pharmacol 1994 v37, 125

What is the true clinical significance of plasma protein binding
displacement interactions
Sansom & Evans
Drug Safety, v12, 227, 1995.

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On 7 Aug 1998 at 11:26:57, Stephen Duffull (sduffull.-a-.fs1.pa.man.ac.uk) sent the message
```
To: A Young

Try:
Rolan PE. Br J Clin Pharmacol 1994;37:125-8

Steve Duffull
```
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