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Does anyone have information about the pharmacokinetics of intravenous
ethamsylate (also referred to as etamsylate or Dicynone)? We have used
it for a patient with extensive small vessel bleeding post-operatively.
Bleeding was unresponsive to DDAVP, Aminocaproic acid, FFP, etc. His
estimated GFR is about 40 - 50 mL/min. Information on fraction of drug
excreted unchanged renally, and half-life of elimination would greatly
assist with initial dosing.
Robert Ariano, Pharm.D., BCPS
Critical Care Pharmacist
St.Boniface General Hospital
Winnipeg, MAN, Canada
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