PharmPK Discussion - Ethamsylate Pharmacokinetics

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On 27 Mar 1998 at 11:03:36, "Dr.Robert E. Ariano" (rariano.-a-.mail.sbgh.mb.ca) sent the message


Does anyone have information about the pharmacokinetics of intravenous
ethamsylate (also referred to as etamsylate or Dicynone)?  We have used
it for a patient with extensive small vessel bleeding post-operatively.
Bleeding was unresponsive to DDAVP, Aminocaproic acid, FFP, etc.  His
estimated GFR is about 40 - 50 mL/min.  Information on fraction of drug
excreted unchanged renally, and half-life of elimination would greatly
assist with initial dosing.
Regards,
Robert Ariano, Pharm.D., BCPS
Critical Care Pharmacist
St.Boniface General Hospital
Winnipeg, MAN, Canada

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