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Dear List,
I'm looking for possible models of insulin action vs. concentration.
Thank you
Dr. Michael H. Giehl
Benjamin Franklin Clinic
D-12200 Berlin, Germany
T. +49-30-8445-2842
F. +49-30-8445-3995
(giehl.-at-.medizin.fu-berlin.de)
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See Woodworth JR et al, Diabetes Care 17: 64-69. Establishment of
Time-Action Profiles for Regular and NPH Insulin Using Pharmacodynamic
Modeling.
Varun Garg
Otsuka America Pharmaceutical, Inc.
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Dear ALL,
1. In general, mechanism of action of insulin is complicated.
2. To simplify, one might assume that insulin stimulates the rate of
metabolism of glucose.
3. In the past Woodworth et.al, Diabetes Care, Vol.17(1), 1994, have used
a distributional-delay model (effect comp.) to charcterize the effect of
insulin conc. on glucose. Unfortunatley, they have insulin conc. below
their EC50 value.
4. However, another way to proceed would be to use an indirect response
model (Model IV) which assumes that the drug stimulates the dissipation of
glucose concentrations.
5. There are more complicated physiological models published elsewhere
(the source is not handy at this time to me).
With regards,
Joga
==============================================================================
Jogarao Gobburu
Center for Drug Development Science
Room NE 405 Med-Dent Building
3900 Reservoir Road NW,
Washington, DC 20007.
Ph : 202-687-7779
Fax: 202-687-0193
E-mail:gobburuj.-a-.gunet.georgetown.edu
www.dml.georgetown.edu/depts/pharmacology/cdds
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