PharmPK Discussion - Lisinopril measurement

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On 2 Apr 1998 at 09:30:41, Jose "P." Urizar (ppurizar.-a-.mpsnet.com.mx) sent the message


Dear all

I am trying to carry out several experiments with lisinopril in the rat,
however, the information on its determination in plasma or whole blood is
 scarce. I would appreciate any direction for HPLC or RIA methods to
measure lisinopril, and if possible commercial data.

Thanks

Jose Perez Urizar  M. Sc.
Seccion de Terapeutica Experimental
Centro de Investigacion y Estudios Avanzados del IPN
Mexico, D.F 16020
e-mail: ppuriza.at.mpsnet.com.mx

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On 3 Apr 1998 at 13:28:28, "CHARLES" (bruce.at.pharmacy.uq.edu.au) sent the message


We developed an assay for urinary lisinopril measurements in view of
its high renal clearance (J. Chromatogr. B 673 (1995) 306-310). In
this paper we have quoted a couple of RIA methods which (at that
time) were not available commercially.

Good luck
BC

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +
Bruce CHARLES, PhD
School of Pharmacy
The University of Queensland
Brisbane, Qld, Australia 4072

Telephone  : +61 7 336 53194
Facsimile     : +61 7 336 51688
Email           :   Bruce.Charles.-at-.pharmacy.uq.edu.au

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

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On 6 Apr 1998 at 15:39:47, Nasir Mohammad Idkaidek (dekaidek.-at-.just.edu.jo) sent the message
```
Try refering to some publications by Freidman & Amidon. Alot has been
done with ACE inhibitors in their labs.
```
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