Back to the Top
Dear All:
Does anyone have a recommendation for the maximum infusion rate and volume
that may be 'safely' administered to rats?
Joe Balthasar, PhD
University of Utah
Back to the Top
[A few replies - db]
From: "VORA, JAYESH"
To: "'PharmPK.at.pharm.cpb.uokhsc.edu'"
Subject: RE: PharmPK Maximum infusion rate / volume for rat PK/PD studies
Date: Fri, 11 Dec 1998 15:13:06 -0500
MIME-Version: 1.0
Check out the following reference:
Hull, RM. Guideline limit volume for dosing animals in the preclinical
stage of safety evaluation. Human and Experimental Toxicology, 1995 14:
305-7.
Jay Vora, Ph.D.
Parke-Davis Pharmaceutical Research
Ann Arbor, MI
---
Date: Fri, 11 Dec 1998 15:24:36 -0500
From: Mauricio Leal
To: PharmPK.-at-.pharm.cpb.uokhsc.edu
Subject: Re: PharmPK Maximum infusion rate / volume for rat PK/PD
studies
Mime-Version: 1.0
Joe:
Maximum volume for a rat is around 20 mL/kg (although it is ideal ~ 5 mL/kg
IV) . As for the maximum infusion rate, that would depend on your compound
and its toxicity.
Mauricio Leal
W-AR
---
Date: Fri, 11 Dec 1998 18:04:37 -0500
From: Amparo
Organization: University of Florida
MIME-Version: 1.0
To: PharmPK.-at-.pharm.cpb.uokhsc.edu
Subject: Re: PharmPK Maximum infusion rate / volume for rat PK/PD studies
We have used an infusion rate of 2 mL/hour for up to 7 hours in rats
that weighed approximately 350 g.
Amparo de la Pena
Dept. of Pharmaceutics
University of Florida
Back to the Top
Dear Joe,
You should refer to the Hull paper in Human and Experimental Toxicology,
1995 (14). It provides all you need to know about administration in rats.
An infusion rate around 2ml/hour is what is normally accepted as a maximum
dosage regimen in rodent (both IV and IP).
Actually, it depends on the very nature of your work: "on/off" studies
designed to provide clues about basic toxicology or rough PK data can be
carried out without refering to such guidelines (as long as you stay in
physiological values).
For example, althrough a 1ml/100mg is the maximum volume commonly given I=
P
in mice, we had to more than double this value in a DL50 study to overcome
solubility problems, with no visible consequence for the animals.
Such work can't be published or used in a drug development project, because
it is off the limits, but it still provides you useful data about a compound=
=2E
I hope this helps,
Pr. Jacques Catalin
Laboratoire de Toxicocinetique et Pharmacocinetique
Facult=E9 de Pharmacie
27, Bd Jean Moulin
13385 Marseille cedex 05
France
Tel: (33) (0)4 91 83 55 09
Fax: (33) (0)4 91 83 56 67
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)