PharmPK Discussion - Metabolism of troglitazone

• On 1 Dec 1998 at 10:49:45, "Kartik shankar" (kartik_shankar.aaa.hotmail.com) sent the message
  

  
  i would like to know something about the metabolism of troglitazone(like
  which enzymes are responsible for the metabolities) and also if more is
  known about the metabolite which may cause any/some hepatic effects.
  please give references if possible.
  
  Kartik Shankar
  
  

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• On 2 Dec 1998 at 15:08:42, ml11439.at.goodnet.com (Michael J. Leibold) sent the message
  

  
  Dear Kartik,
  
      There is a review article on troglitazone in the March 1998 edition of
  Annals of Pharmacotherapy by Johnson, M.D. et al page 337-348. In this
  article they cite one published article on the pharmacokinetics of
  troglitazone in humans (Izumi et al J.Pharmacol Exp Ther 1996;277:1630-41).
  Otherwise the pharmacokinetic data thay they use was obtained from the files
  of the manufacturer (Parke-Davis).
  
       They report that troglitazone is metabolized by the CYP450 isoenzymes
  to some extent, and may interact with drugs which are metabolized by these
  enzymes.
  It is metabolized to a sulfate and quinone of the parent compound, which is
  an alpha-tocopherol substituted thiazodolidinedione.
  
      Mike Leibold, PharmD
      ML11439.-a-.goodnet.com
  
  

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