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Dear Colleagues,
I would like to determine different pharmacokinetic parameters (Vd, t1/2,
Cmax, Cmin, Tmax, Tmin, AUC, Kel) after single and multiple doses of drugs
in mice (per os, IV, IM, Sc). According to your experience which simple,
easy to use Pk Software I can buy and from whom.
Abdel/
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go to internet address: www.aut.ee.ethz/~keller/pharmacalc.html
there is a very handy simulation package which you can download free for a
one-compartment model with various routes of administration and regimens.
art straughn
ut memphis
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[Also check out Pharmatutor at the same site. Thanks Daniel, Art - db]
Sorry to all,
The current and correct address for the calculator is:
http://www.control.ethz.ch/~keller/pharmacalc.html
Note you can search internet for PHARMACALC and it gets you there as well.
There is another program there called pharmasim which is kind of neat.
Art Straughn
UT Memphis
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[A few replies - db]
Reply-To: "Thomas Senderovitz"
From: "Thomas Senderovitz"
To:
Subject: Sv: PharmPK Pk Software for window 95
Date: Sat, 10 Oct 1998 01:46:13 +0100
MIME-Version: 1.0
X-Priority: 3
Dear Abdel,
I find the WinNonlin software very easy to work with, and it has a good
graphical interface.
You can get more information on www.pharsight.com
Kind regards,
Thomas Senderovitz, MD.
E-mail: senderovitz.aaa.dadlnet.dk
---
X-Sender: dfarrier.at.mail.bright.net
Date: Sat, 10 Oct 1998 00:35:25 -0700
To: PharmPK.-at-.pharm.cpb.uokhsc.edu
From: "David S. Farrier"
Subject: Re: PharmPK Pk Software for window 95
Mime-Version: 1.0
Abdel,
Glad you asked, as I am sure others will be too.
For a simple, easy, all-in-one pharmacokinetics program that will do all
you mentioned and more in about four mouse clicks try "PK SOLUTIONS." It is
easy, Excel-based, interactive and comprehensive. Calculating 75 parameters
instantly for a data set, it fills the gap for noncompartmental software
and is virtually a cyber-rendition of the standard texts such as
Gibaldi/Perrier and Rowland/Tozer. This one program can do virtually 99% of
the PK parameters typically published in a journal like Drug Metabolism and
Disposition, and it requires no programming or a long learning curve. The
program is used by researchers as well as by educators. It is now in use in
over 18 countries to teach pharmacokinetics to pharmacy and medical
students, and the number increases monthly. The same goes for its research
gathering which amounts to about half of the users.
I could go on, but we have tried to provide all the details, a demo copy, a
free pamphlet compiling all 85 PK equations embodied by the program, and
ordering information in one place on our web site at
http:www.bright.net/~dfarrier
It is not the only PK program out there, but is was designed to do exactly
what you stated, which pretty much covers the needs for most of us. By the
way, PK Solutions comes in both Windows and Macintosh versions.
Best regards and good hunting,
David
David S. Farrier, Ph.D.
Summit Research Services
Pharmacokinetics and Metabolism Software
1374 Hillcrest Drive
Ashland, OH 44805 USA
Tel: (419) 289-9207
Email: dfarrier.at.bright.net
Web Site: http://www.bright.net/~dfarrier
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Dear Abdel:
You might consider the USC*PACK programs fron the Lab of Applied
Pharmacokinetics at USC. You can get more info from our web site below.
Thay have an iterative Bayesian and a Nonparametric EM population modeling
package which now inckudes both linerar and nonlinear models.
Sincerely,
Roger Jelliffe
Roger W. Jelliffe, M.D.
Professor of Medicine
Laboratory of Applied Pharmacokinetics
USC School of Medicine
2250 Alcazar St, Los Angeles CA 90033
(323)442-1300, fax (323)442-1302
email = jelliffe.at.hsc.usc.edu
our web page = http://www.usc.edu/hsc/lab_apk/
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