PharmPK Discussion - PKPD modeling of glucose clamp studies?

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On 10 Dec 1998 at 11:24:36, HKAG.-at-.novo.dk (HKAG) sent the message


     Have Any of you some suggestions of how to model clamp studies?

     The data will typically consist of insulin concentration as pk data.
     The dynamic part will be split into two sections: you will have the
     drop in plasma glucose and the glucose infusion rate.

     For the study I'm trying to model two different types of insulin is
     compared, the drop in plasma glucose concentration was the same for
     the two types of insulin, because the infusion of glucose is adjusted
     to keep it at a certain level. So infact the difference between the
     two types of insulin are reflected in different glucose infusion
     rates.

     I have tryed to use the indirect response models. Because I thougt
     that glucose could be used as effect data, and the input (kin) is a
     zero order input function which I could add to my infusion rate. But
     this approach was not very succesful.

     Has anyone any suggestions of how to model data like this??

     Henrik Agersoe
     Novo Nordisk A/S
     Denmark

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