PharmPK Discussion - Prodrug stability

PharmPK Discussion List Archive Index page

On 9 Jun 1998 at 09:12:53, Vakily, Majid (MAJID.VAKILY.at.roche.com) sent the message

Hi,

We are going to evaluate few ester prodrug. The main idea is to improve
the bioavil. of the active compound. Therefore, we are looking for the
stability profiles of these prodrugs in plasma or blood, in Simulated
gastric juice, and in the different segments of everted rat intestine.
	Rodents have a higher esterase activity then primates. In
general, esterase activity exhibits marked differences  Is there any
model  with a closer  esterase distribution to man?
	Whole blood or plasma should be used to assess ester prodrug
stability?

	Regards

	Majid

Majid Vakily Ph.D.
------------
Principal Research Scientist
Hoffmann La Roche
Drug Metabolism and Pharmacokinetics/Discovery
Room No 1545
Phone: (201) 235-2251
Fax: (201) 235-7010
Internet e-mail: majid.vakily.-a-.Roche.com

Back to the Top

Want to post a follow-up message on this topic? If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Prodrug stability" as the subject

PharmPK Discussion List Archive Index page