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I would like to know if any one has information about differences in
the plasma protein binding of acidic compounds among various species
(e.g. rats, mice , dogs, and monkeys). We are recently dealing with an
acidic compound which exhibits remarkable differences in protein
binding among various species.
* Is this commonly observed phenomena?
* Is this difference in plasma protein binding impact interspecies
* What are pharmacodynamic consequence of plasma protein binding
differences, particularly, in extrapolating response from animals to
* What is the value of plasma protein binding in the absence of
Majid Vakily Ph.D.
Principal Research Scientist
Hoffmann La Roche
Drug Metabolism and Pharmacokinetics/Discovery
Room No 1545
Phone: (201) 235-2251
Fax: (201) 235-7010
Internet e-mail: majid.vakily.at.Roche.com
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