PharmPK Discussion - Protein binding - acidic - interspecies

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On 2 Mar 1998 at 17:27:34, Vakily, Majid (MAJID.VAKILY.aaa.roche.com) sent the message


Dear Colleagues,

I would like to know if any one has information about differences in
the plasma protein binding of  acidic compounds among various species
(e.g. rats, mice , dogs, and monkeys). We are recently dealing with an
acidic compound which exhibits remarkable differences in protein
binding among various species.

*	Is this commonly observed phenomena?
*	Is this difference in plasma protein binding impact interspecies
scaling?
*	What are pharmacodynamic consequence of plasma protein binding
differences, particularly, in extrapolating response from animals to
man?
*	What is the value of plasma protein binding in the absence of
affinity data?

Thanks

Majid Vakily Ph.D.
---------
Principal Research Scientist
Hoffmann La Roche
Drug Metabolism and Pharmacokinetics/Discovery
Room No 1545
Phone: (201) 235-2251
Fax: (201) 235-7010
Internet e-mail: majid.vakily.at.Roche.com

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