- On 22 Jun 1998 at 12:32:26, Aideen Young (ayoung.-a-.hbase.com) sent the message
Prothrombin times are often reported as International Normalized ratio
(INR) where INR is the ratio of the patient prothrombin time to the
control prothrombin time, raised to the power of the International
Sensitivity Index (ISI). The ISI is the index of the reference
thromboplastin used for the test compared to the WHO reference reagent.
Can anyone give me a reference for the above?
With thanks,
Aideen Young, Ph.D.
Back to the Top
- On 23 Jun 1998 at 11:07:24, David_Bourne (david.aaa.pharm.cpb.uokhsc.edu) sent the message
From: Michelle Sweidan
To: "'PharmPK.at.pharm.cpb.uokhsc.edu'"
Subject: RE: PharmPK Prothrombin times
Date: Tue, 23 Jun 1998 08:50:33 +1200
MIME-Version: 1.0
Dear Aideen
Concept of ISI adopted by WHO in 1982.
Ref: Kirkwood TBL. Calibration of reference thromboplastins and
standardisation of the prothrombin time ratio. Thromb Haemost 1983;
49:238-44.
Michelle Sweidan
---
Date: Mon, 22 Jun 1998 17:22:29 -0400
From: Tom Dowling
MIME-Version: 1.0
To: PharmPK.-at-.pharm.cpb.uokhsc.edu
Subject: Re: PharmPK Prothrombin times
Hi Aideen,
Here are a couple of landmark reports on derivation of INR by Poller.
Hope this helps!
Thomson JM. Tomenson JA. Poller L. The calibration of the second
primary international reference preparation for thromboplastin
(thromboplastin, human, plain, coded BCT/253). Thrombosis &
Haemostasis. 52(3):336-42, 1984 Dec 29.
Poller L. Hirsh J. Special report: a simple system for the derivation
of International Normalized Ratios for the reporting of
prothrombin time results with North American thromboplastin reagents.
American Journal of Clinical Pathology. 92(1):124-6, 1989 Jul.
Tom
----------------------------
Thomas C. Dowling, PharmD
University of Pittsburgh
School of Pharmacy
---
From: "Hoke, Frank"
To: "'PharmPK.at.pharm.cpb.uokhsc.edu'"
Subject: RE: PharmPK Prothrombin times
Date: Tue, 23 Jun 1998 07:24:24 +0100
X-Priority: 3
MIME-Version: 1.0
Aideen
Here's a reference you can try:
World Health Organization. Expert Committee on Biological Standardisation.
33rd Report. WHO Technical Report Series.
Geneva: WHO, 1983:1-105.
Regards
Frank Hoke, PhD
Back to the Top
- On 24 Jun 1998 at 10:16:09, "Dr. Gamal Hussein" (GHussein-clinPharm.aaa.worldnet.att.net) sent the message
The history of standardization of the PT has been extensively reviewed
by Pller and by Kirkwood. I suggest the folowing artilces:
1. Poller L. Progress in standerdization in anticoagulant control.
Hematol Rev 1987;1:225-41
2. Kirkwood TBL. Calibration of reference thromboplastins and
standerdization of the prothrombin time ratio. Thromb Haemost
1983;49:238-44
I would also recommend to look at "the Fourth ACCP (American College of
Chest Physicians) Consenus Conference on Antithrombotic Therapy
published in the Chest, vol 108, number 4. 1995"
Hope this help
Gamal
--
========================
Gamal Hussein, Pharm.D. at http://www.ClinPharmInt.com/Hussein.htm
Associate Professor of Pharmacy
Northeast Louisiana University-Pharmacy School
Associate Professor of Neurology
Louisiana State University-Medical School
Clinical Coordinator of Clinical Pharmacy/Pharmacology Program
The Medical Center of Louisiana at New Orleans
http://www.ClinPharmInt.com/Orleans.htm
email=PYHussein.-at-.Alpha.NLU.edu
Back to the Top
- On 25 Jun 1998 at 08:48:41, "N. Anaizi" (webtent.at.eznet.net) sent the message
Aideen,
You will find a brief synopsis on INR here:
http://home.eznet.net/~webtent/inr.html
Back to the Top